Drug interactions
Fenofibrate micronized + Lovastatin
Severity: Moderate
Fenofibrate micronized and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a fibrate with lovastatin may increase the risk of myopathy and rhabdomyolysis. The risk is lower with fenofibrate than with gemfibrozil but rises with higher statin doses.
What this interaction means in plain words
Fenofibrate micronized and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic myotoxicity of the two lipid-lowering drugs.
What to do
Use only if the benefit justifies it, keep lovastatin at or below 20 mg daily, and tell patients to report muscle pain; check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Fenofibrate micronized with Lovastatin?
MediHelp rates the interaction as moderate. Fenofibrate micronized and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a fibrate with lovastatin may increase the risk of myopathy and rhabdomyolysis. The risk is lower with fenofibrate than with gemfibrozil but rises with higher statin doses.
How serious is the interaction between Fenofibrate micronized and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if the benefit justifies it, keep lovastatin at or below 20 mg daily, and tell patients to report muscle pain; check CK if symptoms occur.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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