Drug interactions
Fenofibrate micronized + Pravastatin
Severity: Moderate
Fenofibrate micronized and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates combined with statins can raise the risk of myopathy and rhabdomyolysis. The risk is lower with fenofibrate and pravastatin than with gemfibrozil combinations, since there is little pharmacokinetic interaction.
What this interaction means in plain words
Fenofibrate micronized and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myotoxicity of the two lipid-lowering agents, without a major pharmacokinetic interaction.
What to do
Use the lowest effective doses and counsel patients to report unexplained muscle pain or weakness. Check CK if symptoms occur, and watch renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Frequently asked questions
Can I take Fenofibrate micronized with Pravastatin?
MediHelp rates the interaction as moderate. Fenofibrate micronized and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates combined with statins can raise the risk of myopathy and rhabdomyolysis. The risk is lower with fenofibrate and pravastatin than with gemfibrozil combinations, since there is little pharmacokinetic interaction.
How serious is the interaction between Fenofibrate micronized and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients to report unexplained muscle pain or weakness. Check CK if symptoms occur, and watch renal function.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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