Drug interactions
Fenofibrate micronized + Ribociclib
Severity: Minor
Fenofibrate micronized and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate is not significantly cleared by CYP3A4; it is hydrolyzed to fenofibric acid and glucuronidated. No meaningful pharmacokinetic interaction with ribociclib is expected.
What this interaction means in plain words
Fenofibrate micronized and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; fenofibric acid is not a major CYP3A4 substrate.
What to do
No dose adjustment is needed. Monitor liver enzymes, as both drugs can raise them.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenofibrate micronized and Ribociclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Fenofibrate micronized with Ribociclib?
MediHelp rates the interaction as minor. Fenofibrate micronized and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate is not significantly cleared by CYP3A4; it is hydrolyzed to fenofibric acid and glucuronidated. No meaningful pharmacokinetic interaction with ribociclib is expected.
How serious is the interaction between Fenofibrate micronized and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor liver enzymes, as both drugs can raise them.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
