Drug interactions
Fenofibrate micronized + Rosuvastatin
Severity: Moderate
Fenofibrate micronized and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining fibrates with statins can increase the risk of myopathy and rhabdomyolysis. With fenofibrate the risk is lower than with gemfibrozil, but still present.
What this interaction means in plain words
Fenofibrate micronized and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myotoxicity; fenofibrate does not significantly alter rosuvastatin pharmacokinetics.
What to do
Use the combination only when needed for severe mixed dyslipidemia and use the lowest effective doses. Counsel the patient to report muscle pain and check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Fenofibrate micronized with Rosuvastatin?
MediHelp rates the interaction as moderate. Fenofibrate micronized and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining fibrates with statins can increase the risk of myopathy and rhabdomyolysis. With fenofibrate the risk is lower than with gemfibrozil, but still present.
How serious is the interaction between Fenofibrate micronized and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the combination only when needed for severe mixed dyslipidemia and use the lowest effective doses. Counsel the patient to report muscle pain and check CK if symptoms occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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