Drug interactions
Fenoldopam + Labetalol
Severity: Moderate
Fenoldopam and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is a short-acting vasodilator used for severe hypertension, and combining it with labetalol can cause additive blood pressure reduction. Beta blockers may also blunt the reflex tachycardia that fenoldopam produces.
What this interaction means in plain words
Fenoldopam and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from dopamine-1 agonist vasodilation plus alpha/beta adrenergic blockade.
What to do
Monitor blood pressure continuously during fenoldopam infusion and titrate cautiously. Reduce the infusion rate if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Fenoldopam with Labetalol?
MediHelp rates the interaction as moderate. Fenoldopam and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is a short-acting vasodilator used for severe hypertension, and combining it with labetalol can cause additive blood pressure reduction. Beta blockers may also blunt the reflex tachycardia that fenoldopam produces.
How serious is the interaction between Fenoldopam and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during fenoldopam infusion and titrate cautiously. Reduce the infusion rate if hypotension occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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