Drug interactions
Fenoldopam + Metoprolol
Severity: Moderate
Fenoldopam and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is an intravenous vasodilator for severe hypertension, and beta-blockers can add to the blood pressure fall. Beta-blockade may also blunt the reflex tachycardia that normally accompanies fenoldopam, so excessive hypotension is possible.
What this interaction means in plain words
Fenoldopam and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from dopamine D1-mediated vasodilation and beta-blockade, with blunted reflex tachycardia.
What to do
Titrate fenoldopam with continuous blood pressure monitoring in patients on metoprolol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Fenoldopam with Metoprolol?
MediHelp rates the interaction as moderate. Fenoldopam and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is an intravenous vasodilator for severe hypertension, and beta-blockers can add to the blood pressure fall. Beta-blockade may also blunt the reflex tachycardia that normally accompanies fenoldopam, so excessive hypotension is possible.
How serious is the interaction between Fenoldopam and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate fenoldopam with continuous blood pressure monitoring in patients on metoprolol.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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