Drug interactions
Fenoprofen + Gentamicin
Severity: Major
Fenoprofen and Gentamicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides and add to nephrotoxicity, leading to higher gentamicin concentrations and increased risk of kidney injury and ototoxicity. This has been documented particularly in neonates and in renal impairment.
What this interaction means in plain words
Fenoprofen and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Gentamicin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and glomerular filtration, decreasing aminoglycoside elimination and adding nephrotoxic injury.
What to do
Avoid the NSAID during aminoglycoside therapy where possible; otherwise monitor gentamicin levels and serum creatinine closely and adjust dosing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Fenoprofen with Gentamicin?
MediHelp rates the interaction as major. Fenoprofen and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce renal clearance of aminoglycosides and add to nephrotoxicity, leading to higher gentamicin concentrations and increased risk of kidney injury and ototoxicity. This has been documented particularly in neonates and in renal impairment.
How serious is the interaction between Fenoprofen and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the NSAID during aminoglycoside therapy where possible; otherwise monitor gentamicin levels and serum creatinine closely and adjust dosing.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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