Drug interactions
Fenoprofen + Imidapril
Severity: Moderate
Fenoprofen and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can reduce the antihypertensive effect of imidapril. In volume-depleted, elderly or renally impaired patients the combination may also cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Fenoprofen and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Imidapril belongs to Cardiovascular.
Why it happens
NSAIDs inhibit vasodilatory prostaglandins and cause sodium retention, opposing ACE inhibitor effects and reducing renal perfusion.
What to do
Monitor blood pressure, creatinine and potassium, especially at initiation and in high-risk patients. Ensure adequate hydration and limit NSAID duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenoprofen and Imidapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Fenoprofen with Imidapril?
MediHelp rates the interaction as moderate. Fenoprofen and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can reduce the antihypertensive effect of imidapril. In volume-depleted, elderly or renally impaired patients the combination may also cause acute kidney injury and hyperkalemia.
How serious is the interaction between Fenoprofen and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, especially at initiation and in high-risk patients. Ensure adequate hydration and limit NSAID duration.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
