Drug interactions
Fenoprofen + Labetalol
Severity: Moderate
Fenoprofen and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use such as fenoprofen can reduce the blood pressure lowering effect of labetalol. The effect varies between patients and is usually modest.
What this interaction means in plain words
Fenoprofen and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Labetalol belongs to Cardiovascular.
Why it happens
NSAIDs inhibit vasodilatory prostaglandin synthesis and promote sodium and fluid retention, opposing antihypertensive action.
What to do
Monitor blood pressure when the NSAID is started, changed or stopped, and adjust the antihypertensive dose if needed. Prefer the shortest NSAID course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Fenoprofen with Labetalol?
MediHelp rates the interaction as moderate. Fenoprofen and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use such as fenoprofen can reduce the blood pressure lowering effect of labetalol. The effect varies between patients and is usually modest.
How serious is the interaction between Fenoprofen and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the NSAID is started, changed or stopped, and adjust the antihypertensive dose if needed. Prefer the shortest NSAID course.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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