Drug interactions
Fenoprofen + Levomilnacipran
Severity: Moderate
Fenoprofen and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs impair platelet serotonin uptake and, with NSAIDs, raise the risk of bleeding, particularly gastrointestinal bleeding. Risk is higher in older adults and those with a history of ulcers.
What this interaction means in plain words
Fenoprofen and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Levomilnacipran belongs to Central Nervous System.
Why it happens
Serotonin depletion in platelets impairs aggregation, adding to NSAID cyclooxygenase inhibition and mucosal injury.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in high-risk patients; use paracetamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Fenoprofen with Levomilnacipran?
MediHelp rates the interaction as moderate. Fenoprofen and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs impair platelet serotonin uptake and, with NSAIDs, raise the risk of bleeding, particularly gastrointestinal bleeding. Risk is higher in older adults and those with a history of ulcers.
How serious is the interaction between Fenoprofen and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in high-risk patients; use paracetamol where possible.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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