Drug interactions
Fenoprofen + Pegaspargase
Severity: Moderate
Fenoprofen and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can cause coagulopathy and thrombocytopenia through reduced clotting factor synthesis. NSAIDs impair platelet function and can damage the gastric mucosa, so bleeding risk is increased.
What this interaction means in plain words
Fenoprofen and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Additive hemostatic impairment: asparaginase-related coagulation factor deficiency plus NSAID platelet inhibition.
What to do
Avoid NSAIDs during pegaspargase therapy where possible and use paracetamol instead. Monitor platelets, fibrinogen and coagulation tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Fenoprofen with Pegaspargase?
MediHelp rates the interaction as moderate. Fenoprofen and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can cause coagulopathy and thrombocytopenia through reduced clotting factor synthesis. NSAIDs impair platelet function and can damage the gastric mucosa, so bleeding risk is increased.
How serious is the interaction between Fenoprofen and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs during pegaspargase therapy where possible and use paracetamol instead. Monitor platelets, fibrinogen and coagulation tests.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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