Drug interactions
Etodolac + Pegaspargase
Severity: Major
Etodolac and Pegaspargase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can cause coagulation abnormalities, including low fibrinogen and thrombocytopenia, and NSAIDs add antiplatelet effects and GI irritation. Bleeding risk is therefore increased.
What this interaction means in plain words
Etodolac and Pegaspargase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Additive hemostatic impairment: asparaginase-related reduction in clotting factor synthesis combined with NSAID platelet inhibition.
What to do
Avoid NSAIDs during pegaspargase therapy where possible and use paracetamol. Monitor platelet count, fibrinogen and for bleeding if an NSAID is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Pegaspargase
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
- Dabigatran etexilate + Pegaspargase Moderate
Frequently asked questions
Can I take Etodolac with Pegaspargase?
MediHelp rates the interaction as major. Etodolac and Pegaspargase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pegaspargase can cause coagulation abnormalities, including low fibrinogen and thrombocytopenia, and NSAIDs add antiplatelet effects and GI irritation. Bleeding risk is therefore increased.
How serious is the interaction between Etodolac and Pegaspargase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs during pegaspargase therapy where possible and use paracetamol. Monitor platelet count, fibrinogen and for bleeding if an NSAID is unavoidable.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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