Drug interactions
Celecoxib + Pegaspargase
Severity: Moderate
Celecoxib and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can cause coagulation abnormalities and thrombocytopenia, and NSAIDs add antiplatelet and mucosal effects, raising bleeding risk. The interaction is mainly additive pharmacodynamics.
What this interaction means in plain words
Celecoxib and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Asparaginase-induced depletion of clotting factors combined with NSAID platelet inhibition.
What to do
Monitor coagulation parameters and platelet counts, and avoid NSAIDs when counts are low or bleeding is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Dabigatran etexilate + Pegaspargase Moderate
Frequently asked questions
Can I take Celecoxib with Pegaspargase?
MediHelp rates the interaction as moderate. Celecoxib and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can cause coagulation abnormalities and thrombocytopenia, and NSAIDs add antiplatelet and mucosal effects, raising bleeding risk. The interaction is mainly additive pharmacodynamics.
How serious is the interaction between Celecoxib and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor coagulation parameters and platelet counts, and avoid NSAIDs when counts are low or bleeding is present.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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