Drug interactions
Argatroban + Pegaspargase
Severity: Moderate
Argatroban and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase lowers synthesis of coagulation factors and can cause both bleeding and thrombosis. With argatroban, bleeding risk is increased, and baseline coagulopathy can also make aPTT monitoring harder to interpret.
What this interaction means in plain words
Argatroban and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Pegaspargase belongs to Oncology.
Why it happens
Asparaginase-induced depletion of clotting factors adds to anticoagulant effect.
What to do
Monitor coagulation parameters including fibrinogen and aPTT, and watch for bleeding. Adjust argatroban dosing based on clinical and laboratory response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
- Dabigatran etexilate + Pegaspargase Moderate
Frequently asked questions
Can I take Argatroban with Pegaspargase?
MediHelp rates the interaction as moderate. Argatroban and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase lowers synthesis of coagulation factors and can cause both bleeding and thrombosis. With argatroban, bleeding risk is increased, and baseline coagulopathy can also make aPTT monitoring harder to interpret.
How serious is the interaction between Argatroban and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor coagulation parameters including fibrinogen and aPTT, and watch for bleeding. Adjust argatroban dosing based on clinical and laboratory response.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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