Drug interactions
Fenoprofen + Piroxicam
Severity: Major
Fenoprofen and Piroxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds no proven therapeutic benefit and increases the risk of gastrointestinal ulceration and bleeding, renal impairment and fluid retention. Both drugs also impair platelet function.
What this interaction means in plain words
Fenoprofen and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Piroxicam belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition leads to greater loss of gastroprotective prostaglandins, platelet inhibition and reduced renal perfusion.
What to do
Avoid concurrent use of two systemic NSAIDs and use a single agent at the lowest effective dose. If GI risk is high, add gastroprotection and monitor for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Fenoprofen with Piroxicam?
MediHelp rates the interaction as major. Fenoprofen and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs adds no proven therapeutic benefit and increases the risk of gastrointestinal ulceration and bleeding, renal impairment and fluid retention. Both drugs also impair platelet function.
How serious is the interaction between Fenoprofen and Piroxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two systemic NSAIDs and use a single agent at the lowest effective dose. If GI risk is high, add gastroprotection and monitor for bleeding and renal function.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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