Drug interactions
Fenoprofen + Rivaroxaban
Severity: Major
Fenoprofen and Rivaroxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using an NSAID with rivaroxaban increases the risk of clinically significant bleeding, particularly gastrointestinal bleeding. The risk arises from combined effects on platelet function, mucosal integrity and coagulation.
What this interaction means in plain words
Fenoprofen and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Rivaroxaban belongs to Cardiovascular.
Why it happens
NSAIDs inhibit platelet aggregation and injure GI mucosa, adding to the factor Xa inhibition by rivaroxaban.
What to do
Avoid the combination when possible and use paracetamol or another alternative. If needed, use the shortest course with gastroprotection and monitor for bleeding and anemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Fenoprofen with Rivaroxaban?
MediHelp rates the interaction as major. Fenoprofen and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using an NSAID with rivaroxaban increases the risk of clinically significant bleeding, particularly gastrointestinal bleeding. The risk arises from combined effects on platelet function, mucosal integrity and coagulation.
How serious is the interaction between Fenoprofen and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible and use paracetamol or another alternative. If needed, use the shortest course with gastroprotection and monitor for bleeding and anemia.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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