Drug interactions
Fentanyl + Iloperidone
Severity: Moderate
Fentanyl and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is mainly a CYP3A4 and CYP2D6 substrate and is not a recognized meaningful CYP3A4 inhibitor, so a kinetic effect on fentanyl is unlikely. The combination does add CNS depressant and hypotensive effects, with sedation and orthostasis possible.
What this interaction means in plain words
Fentanyl and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from the antipsychotic and opioid; no established CYP3A4 inhibition.
What to do
Monitor for sedation, orthostatic hypotension and respiratory depression, starting with lower doses of each agent. Counsel patients on fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Fentanyl with Iloperidone?
MediHelp rates the interaction as moderate. Fentanyl and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is mainly a CYP3A4 and CYP2D6 substrate and is not a recognized meaningful CYP3A4 inhibitor, so a kinetic effect on fentanyl is unlikely. The combination does add CNS depressant and hypotensive effects, with sedation and orthostasis possible.
How serious is the interaction between Fentanyl and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and respiratory depression, starting with lower doses of each agent. Counsel patients on fall risk.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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