Drug interactions
Fentanyl + Loratadine
Severity: Moderate
Fentanyl and Loratadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl causes significant sedation and respiratory depression, and any additional sedating drug may add to this. Loratadine is minimally sedating, so the added effect is usually small.
What this interaction means in plain words
Fentanyl and Loratadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Loratadine belongs to Respiratory.
Why it happens
Additive central nervous system depression.
What to do
Monitor sedation and respiratory status when starting or titrating, and counsel against driving or alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
- Loratadine + Rifampin Moderate
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Loratadine?
MediHelp rates the interaction as moderate. Fentanyl and Loratadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl causes significant sedation and respiratory depression, and any additional sedating drug may add to this. Loratadine is minimally sedating, so the added effect is usually small.
How serious is the interaction between Fentanyl and Loratadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status when starting or titrating, and counsel against driving or alcohol use.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Isocarboxazid. The full list is on the Loratadine page.
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