Drug interactions
Isocarboxazid + Loratadine
Severity: Moderate
Isocarboxazid and Loratadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may prolong and intensify the anticholinergic and sedative effects of antihistamines. Loratadine is minimally sedating, so the risk is usually limited to mild additive drowsiness or anticholinergic symptoms.
What this interaction means in plain words
Isocarboxazid and Loratadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isocarboxazid belongs to Central Nervous System; Loratadine belongs to Respiratory.
Why it happens
Additive pharmacodynamic CNS depression, with MAO inhibition possibly potentiating antihistamine anticholinergic effects.
What to do
Monitor for sedation and anticholinergic effects when loratadine is used with isocarboxazid. Advise caution with driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
- Loratadine + Rifampin Moderate
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Loratadine?
MediHelp rates the interaction as moderate. Isocarboxazid and Loratadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may prolong and intensify the anticholinergic and sedative effects of antihistamines. Loratadine is minimally sedating, so the risk is usually limited to mild additive drowsiness or anticholinergic symptoms.
How serious is the interaction between Isocarboxazid and Loratadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects when loratadine is used with isocarboxazid. Advise caution with driving until the response is known.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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