Drug interactions
Levoketoconazole + Loratadine
Severity: Moderate
Levoketoconazole and Loratadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can raise loratadine and desloratadine levels, as seen with ketoconazole. Levoketoconazole also prolongs the QT interval, so combined exposure warrants attention even though loratadine itself has low arrhythmic risk.
What this interaction means in plain words
Levoketoconazole and Loratadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Loratadine belongs to Respiratory.
Why it happens
Strong CYP3A4 inhibition reduces loratadine metabolism, increasing plasma concentrations.
What to do
Use the lowest loratadine dose or an alternative such as fexofenadine or cetirizine; monitor ECG if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Loratadine + Mavacamten Moderate
- Loratadine + Rifampin Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Loratadine?
MediHelp rates the interaction as moderate. Levoketoconazole and Loratadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can raise loratadine and desloratadine levels, as seen with ketoconazole. Levoketoconazole also prolongs the QT interval, so combined exposure warrants attention even though loratadine itself has low arrhythmic risk.
How serious is the interaction between Levoketoconazole and Loratadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest loratadine dose or an alternative such as fexofenadine or cetirizine; monitor ECG if other QT-prolonging drugs are present.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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