Drug interactions
Amobarbital + Loratadine
Severity: Moderate
Amobarbital and Loratadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4 and other hepatic enzymes, which may lower loratadine concentrations and reduce its antihistamine effect. Barbiturate sedation may also be additive with antihistamines.
What this interaction means in plain words
Amobarbital and Loratadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Loratadine belongs to Respiratory.
Why it happens
Induction of CYP3A4-mediated metabolism of loratadine by amobarbital, plus additive CNS depression.
What to do
Monitor for reduced allergy control and excess sedation; consider an alternative antihistamine if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
- Loratadine + Rifampin Moderate
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Loratadine?
MediHelp rates the interaction as moderate. Amobarbital and Loratadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces CYP3A4 and other hepatic enzymes, which may lower loratadine concentrations and reduce its antihistamine effect. Barbiturate sedation may also be additive with antihistamines.
How serious is the interaction between Amobarbital and Loratadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced allergy control and excess sedation; consider an alternative antihistamine if efficacy is lost.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Fentanyl, Isocarboxazid. The full list is on the Loratadine page.
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