Drug interactions
Fentanyl + Ribociclib
Severity: Moderate
Fentanyl and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may increase fentanyl exposure, raising the risk of sedation and respiratory depression. The risk is greater with higher or repeated fentanyl doses.
What this interaction means in plain words
Fentanyl and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated fentanyl metabolism by ribociclib.
What to do
Monitor for sedation and respiratory depression and consider reducing the fentanyl dose. Reassess the opioid dose when ribociclib is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Fentanyl with Ribociclib?
MediHelp rates the interaction as moderate. Fentanyl and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may increase fentanyl exposure, raising the risk of sedation and respiratory depression. The risk is greater with higher or repeated fentanyl doses.
How serious is the interaction between Fentanyl and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and consider reducing the fentanyl dose. Reassess the opioid dose when ribociclib is started or stopped.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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