Drug interactions
Fentanyl + Talquetamab
Severity: Moderate
Fentanyl and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release syndrome, and raised cytokines can temporarily suppress CYP enzyme activity. This may increase fentanyl exposure and opioid effects, mainly during step-up dosing and around CRS episodes.
What this interaction means in plain words
Fentanyl and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces fentanyl metabolism.
What to do
Monitor for excess sedation and respiratory depression during step-up dosing and for about 2 weeks after the first treatment dose, and during CRS. Lower the fentanyl dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Fentanyl with Talquetamab?
MediHelp rates the interaction as moderate. Fentanyl and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release syndrome, and raised cytokines can temporarily suppress CYP enzyme activity. This may increase fentanyl exposure and opioid effects, mainly during step-up dosing and around CRS episodes.
How serious is the interaction between Fentanyl and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression during step-up dosing and for about 2 weeks after the first treatment dose, and during CRS. Lower the fentanyl dose if needed.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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