Drug interactions
Clozapine + Talquetamab
Severity: Major
Clozapine and Talquetamab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab can cause cytokine release syndrome, and inflammation suppresses CYP1A2, the main enzyme clearing clozapine. Clozapine levels may rise and cause toxicity such as sedation, seizures, hypotension and myocarditis-like symptoms.
What this interaction means in plain words
Clozapine and Talquetamab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP1A2 reduces clozapine clearance.
What to do
Monitor for clozapine toxicity during step-up dosing and for about two weeks afterwards, and check clozapine levels with dose reduction if toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Talquetamab
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
- Cyclosporin + Talquetamab Moderate
Frequently asked questions
Can I take Clozapine with Talquetamab?
MediHelp rates the interaction as major. Clozapine and Talquetamab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Talquetamab can cause cytokine release syndrome, and inflammation suppresses CYP1A2, the main enzyme clearing clozapine. Clozapine levels may rise and cause toxicity such as sedation, seizures, hypotension and myocarditis-like symptoms.
How serious is the interaction between Clozapine and Talquetamab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clozapine toxicity during step-up dosing and for about two weeks afterwards, and check clozapine levels with dose reduction if toxicity develops.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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