Drug interactions
Clomipramine + Talquetamab
Severity: Moderate
Clomipramine and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome after talquetamab can transiently suppress CYP enzyme activity, which may raise concentrations of CYP substrates such as clomipramine. Higher clomipramine levels could increase anticholinergic, sedative and cardiac toxicity.
What this interaction means in plain words
Clomipramine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP enzymes (including CYP1A2) reduces clomipramine metabolism.
What to do
Monitor for clomipramine toxicity, including sedation, anticholinergic effects and arrhythmia, from the start of step-up dosing through about two weeks after the first treatment dose and during any CRS. Reduce the clomipramine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
- Cyclosporin + Talquetamab Moderate
Frequently asked questions
Can I take Clomipramine with Talquetamab?
MediHelp rates the interaction as moderate. Clomipramine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome after talquetamab can transiently suppress CYP enzyme activity, which may raise concentrations of CYP substrates such as clomipramine. Higher clomipramine levels could increase anticholinergic, sedative and cardiac toxicity.
How serious is the interaction between Clomipramine and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clomipramine toxicity, including sedation, anticholinergic effects and arrhythmia, from the start of step-up dosing through about two weeks after the first treatment dose and during any CRS. Reduce the clomipramine dose if toxicity appears.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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