Drug interactions
Fentanyl intranasal + Flibanserin
Severity: Moderate
Fentanyl intranasal and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl is a potent opioid with CNS and respiratory depressant effects, and flibanserin adds sedation and hypotension. Together they increase the risk of oversedation and impaired psychomotor function.
What this interaction means in plain words
Fentanyl intranasal and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and respiratory depression, and counsel against driving; consider avoiding flibanserin during opioid titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Fentanyl intranasal with Flibanserin?
MediHelp rates the interaction as moderate. Fentanyl intranasal and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl is a potent opioid with CNS and respiratory depressant effects, and flibanserin adds sedation and hypotension. Together they increase the risk of oversedation and impaired psychomotor function.
How serious is the interaction between Fentanyl intranasal and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory depression, and counsel against driving; consider avoiding flibanserin during opioid titration.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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