Drug interactions
Fentanyl intranasal + Furosemide
Severity: Minor
Fentanyl intranasal and Furosemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as fentanyl can stimulate antidiuretic hormone release and may urinary retention, reducing the effect of furosemide. Hypotension may also be additive in volume-depleted patients.
What this interaction means in plain words
Fentanyl intranasal and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release and urinary retention oppose diuresis.
What to do
Monitor fluid balance, urine output and blood pressure, and adjust the furosemide dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Fentanyl intranasal with Furosemide?
MediHelp rates the interaction as minor. Fentanyl intranasal and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids such as fentanyl can stimulate antidiuretic hormone release and may urinary retention, reducing the effect of furosemide. Hypotension may also be additive in volume-depleted patients.
How serious is the interaction between Fentanyl intranasal and Furosemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid balance, urine output and blood pressure, and adjust the furosemide dose as needed.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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