Drug interactions
Fentanyl intranasal + Lurasidone
Severity: Moderate
Fentanyl intranasal and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and antipsychotics both depress the CNS. Together they can cause deeper sedation, hypotension and respiratory depression.
What this interaction means in plain words
Fentanyl intranasal and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression (pharmacodynamic).
What to do
Use the lowest effective opioid dose and monitor sedation and respiratory rate, especially at initiation and dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Fentanyl intranasal with Lurasidone?
MediHelp rates the interaction as moderate. Fentanyl intranasal and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids and antipsychotics both depress the CNS. Together they can cause deeper sedation, hypotension and respiratory depression.
How serious is the interaction between Fentanyl intranasal and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor sedation and respiratory rate, especially at initiation and dose changes.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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