Drug interactions
Fentanyl iontophoretic transdermal system + Fluphenazine
Severity: Major
Fentanyl iontophoretic transdermal system and Fluphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl and fluphenazine both depress the CNS, so concurrent use can cause profound sedation, hypotension and respiratory depression. Opioid-sedative combinations carry labeled warnings for coma and death in vulnerable patients.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Fluphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with added hypotension from phenothiazine alpha-blockade.
What to do
Reserve co-prescribing for patients without alternatives, use the lowest effective doses, and monitor respiratory rate, sedation level and blood pressure closely. Counsel patients on the risks of driving or using alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Fluphenazine?
MediHelp rates the interaction as major. Fentanyl iontophoretic transdermal system and Fluphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fentanyl and fluphenazine both depress the CNS, so concurrent use can cause profound sedation, hypotension and respiratory depression. Opioid-sedative combinations carry labeled warnings for coma and death in vulnerable patients.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Fluphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve co-prescribing for patients without alternatives, use the lowest effective doses, and monitor respiratory rate, sedation level and blood pressure closely. Counsel patients on the risks of driving or using alcohol.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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