Drug interactions
Fentanyl iontophoretic transdermal system + Haloperidol
Severity: Moderate
Fentanyl iontophoretic transdermal system and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol and fentanyl both depress the central nervous system. Taken together they can produce deeper sedation, psychomotor impairment and, particularly in vulnerable patients, respiratory depression and hypotension.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of an antipsychotic and an opioid.
What to do
Monitor sedation level, respiratory rate and blood pressure, especially during initiation and dose changes. Use the lowest effective doses and counsel patients against driving or other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Haloperidol?
MediHelp rates the interaction as moderate. Fentanyl iontophoretic transdermal system and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol and fentanyl both depress the central nervous system. Taken together they can produce deeper sedation, psychomotor impairment and, particularly in vulnerable patients, respiratory depression and hypotension.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, respiratory rate and blood pressure, especially during initiation and dose changes. Use the lowest effective doses and counsel patients against driving or other hazardous activities.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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