Drug interactions
Fentanyl iontophoretic transdermal system + Hydroxyzine
Severity: Major
Fentanyl iontophoretic transdermal system and Hydroxyzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine may add to fentanyl-related sedation and respiratory depression. This is a particular concern in monitored postoperative settings where several sedating drugs are used.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Hydroxyzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1-antihistamine sedation.
What to do
Limit combined use to patients without suitable alternatives and use the lowest hydroxyzine dose. Monitor sedation level and respiratory rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Hydroxyzine?
MediHelp rates the interaction as major. Fentanyl iontophoretic transdermal system and Hydroxyzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hydroxyzine may add to fentanyl-related sedation and respiratory depression. This is a particular concern in monitored postoperative settings where several sedating drugs are used.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Hydroxyzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit combined use to patients without suitable alternatives and use the lowest hydroxyzine dose. Monitor sedation level and respiratory rate.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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