Drug interactions
Fentanyl iontophoretic transdermal system + Perphenazine
Severity: Moderate
Fentanyl iontophoretic transdermal system and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl is a potent opioid, and combining it with perphenazine increases sedation, hypotension and risk of respiratory depression.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Monitor sedation level and respiratory rate, and avoid other CNS depressants. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Perphenazine?
MediHelp rates the interaction as moderate. Fentanyl iontophoretic transdermal system and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl is a potent opioid, and combining it with perphenazine increases sedation, hypotension and risk of respiratory depression.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, and avoid other CNS depressants. Reduce doses if excessive sedation occurs.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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