Drug interactions
Ferrous sulfate + Gemifloxacin
Severity: Moderate
Ferrous sulfate and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron binds gemifloxacin in the gut and markedly reduces its absorption, risking subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Ferrous sulfate and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous sulfate belongs to Miscellaneous; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Chelation of gemifloxacin by ferrous iron in the gastrointestinal tract, reducing absorption.
What to do
Give gemifloxacin at least 2 hours before or 3 hours after iron. Postpone iron if possible during short antibiotic courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Ferrous sulfate
Frequently asked questions
Can I take Ferrous sulfate with Gemifloxacin?
MediHelp rates the interaction as moderate. Ferrous sulfate and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron binds gemifloxacin in the gut and markedly reduces its absorption, risking subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Ferrous sulfate and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give gemifloxacin at least 2 hours before or 3 hours after iron. Postpone iron if possible during short antibiotic courses.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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