Drug interactions
Ferrous sulfate + Omadacycline
Severity: Moderate
Ferrous sulfate and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron can bind oral omadacycline in the gut and decrease its absorption, possibly reducing antibacterial efficacy.
What this interaction means in plain words
Ferrous sulfate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous sulfate belongs to Miscellaneous; Omadacycline belongs to Anti Bacterial.
Why it happens
Chelation of omadacycline by iron in the gastrointestinal tract reduces absorption.
What to do
Avoid taking iron within about 4 hours of oral omadacycline, which should be taken fasting, and separate doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferrous sulfate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Ferrous sulfate with Omadacycline?
MediHelp rates the interaction as moderate. Ferrous sulfate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron can bind oral omadacycline in the gut and decrease its absorption, possibly reducing antibacterial efficacy.
How serious is the interaction between Ferrous sulfate and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking iron within about 4 hours of oral omadacycline, which should be taken fasting, and separate doses accordingly.
What other medicines interact with Ferrous sulfate?
MediHelp also lists interactions of Ferrous sulfate with, for example, Ciprofloxacin, Dimercaprol, Acetohydroxamic acid. The full list is on the Ferrous sulfate page.
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