Drug interactions
Amoxicillin + Omadacycline
Severity: Moderate
Amoxicillin and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracyclines may blunt the bactericidal effect of penicillins. Clinical data are limited.
What this interaction means in plain words
Amoxicillin and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amoxicillin belongs to Anti Bacterial; Omadacycline belongs to Anti Bacterial.
Why it happens
Bacteriostatic inhibition of protein synthesis reduces growth-dependent beta-lactam killing.
What to do
Avoid the combination in severe infections requiring bactericidal activity; otherwise monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Ampicillin-sulbactam + Omadacycline Moderate
Frequently asked questions
Can I take Amoxicillin with Omadacycline?
MediHelp rates the interaction as moderate. Amoxicillin and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines may blunt the bactericidal effect of penicillins. Clinical data are limited.
How serious is the interaction between Amoxicillin and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in severe infections requiring bactericidal activity; otherwise monitor clinical response.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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