Drug interactions
Amoxicillin-clavulanic acid + Omadacycline
Severity: Moderate
Amoxicillin-clavulanic acid and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omadacycline is a bacteriostatic tetracycline that may theoretically blunt penicillin bactericidal effects. There is limited clinical evidence of harm. Relevance is greatest in serious infections.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Omadacycline belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: inhibition of bacterial growth reduces the activity of beta-lactams that act on dividing cells.
What to do
Avoid combining for severe infections unless dual therapy is clearly justified. Monitor clinical response if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
- Ampicillin-sulbactam + Omadacycline Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Omadacycline?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omadacycline is a bacteriostatic tetracycline that may theoretically blunt penicillin bactericidal effects. There is limited clinical evidence of harm. Relevance is greatest in serious infections.
How serious is the interaction between Amoxicillin-clavulanic acid and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining for severe infections unless dual therapy is clearly justified. Monitor clinical response if used together.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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