Drug interactions
Fesoterodine + Fluoxetine
Severity: Minor
Fesoterodine and Fluoxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is a potent CYP2D6 inhibitor and may raise exposure to the active metabolite of fesoterodine. The effect is modest because CYP3A4 provides an alternative pathway, but antimuscarinic adverse effects may increase.
What this interaction means in plain words
Fesoterodine and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Fluoxetine belongs to Central Nervous System.
Why it happens
Fluoxetine inhibits CYP2D6, reducing clearance of the active fesoterodine metabolite.
What to do
No empirical dose change; monitor for anticholinergic effects and reduce fesoterodine if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fesoterodine with Fluoxetine?
MediHelp rates the interaction as minor. Fesoterodine and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine is a potent CYP2D6 inhibitor and may raise exposure to the active metabolite of fesoterodine. The effect is modest because CYP3A4 provides an alternative pathway, but antimuscarinic adverse effects may increase.
How serious is the interaction between Fesoterodine and Fluoxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor for anticholinergic effects and reduce fesoterodine if they become troublesome.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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