Drug interactions
Fesoterodine + Levodopa
Severity: Minor
Fesoterodine and Levodopa: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergics such as fesoterodine can slow gastric emptying, which may reduce levodopa absorption. They may also worsen tardive dyskinesia, although some additive antiparkinsonian effect can occur.
What this interaction means in plain words
Fesoterodine and Levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Levodopa belongs to Central Nervous System.
Why it happens
Anticholinergic slowing of gastrointestinal motility delays levodopa absorption, with additive pharmacodynamic effects.
What to do
Monitor for changes in parkinsonian control, dyskinesia and constipation. Adjust the levodopa regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Fesoterodine with Levodopa?
MediHelp rates the interaction as minor. Fesoterodine and Levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anticholinergics such as fesoterodine can slow gastric emptying, which may reduce levodopa absorption. They may also worsen tardive dyskinesia, although some additive antiparkinsonian effect can occur.
How serious is the interaction between Fesoterodine and Levodopa?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for changes in parkinsonian control, dyskinesia and constipation. Adjust the levodopa regimen if control worsens.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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