Drug interactions
Fesoterodine + Loxapine
Severity: Moderate
Fesoterodine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has anticholinergic activity, so combining it with fesoterodine adds to antimuscarinic adverse effects. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
What this interaction means in plain words
Fesoterodine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Loxapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects and cognitive changes. Use the lowest effective doses and review the need for both drugs in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Fesoterodine with Loxapine?
MediHelp rates the interaction as moderate. Fesoterodine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has anticholinergic activity, so combining it with fesoterodine adds to antimuscarinic adverse effects. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
How serious is the interaction between Fesoterodine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and cognitive changes. Use the lowest effective doses and review the need for both drugs in older adults.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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