Drug interactions
Fesoterodine + Memantine-donepezil
Severity: Moderate
Fesoterodine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fesoterodine is an antimuscarinic and opposes the effect of donepezil, reducing the benefit of each. Anticholinergic burden may also worsen cognition in dementia.
What this interaction means in plain words
Fesoterodine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor cognition and urinary symptoms. Consider mirabegron or non-drug measures instead of an antimuscarinic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Fesoterodine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fesoterodine is an antimuscarinic and opposes the effect of donepezil, reducing the benefit of each. Anticholinergic burden may also worsen cognition in dementia.
How serious is the interaction between Fesoterodine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and urinary symptoms. Consider mirabegron or non-drug measures instead of an antimuscarinic.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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