Drug interactions
Fesoterodine + Oliceridine
Severity: Moderate
Fesoterodine and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastrointestinal transit and can cause urinary retention, and antimuscarinics add to these effects. Together they raise the risk of severe constipation and paralytic ileus.
What this interaction means in plain words
Fesoterodine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive reduction of gastrointestinal motility and bladder emptying via opioid and antimuscarinic effects.
What to do
Monitor for urinary retention and reduced bowel activity, and use a prophylactic bowel regimen. Stop or reduce one agent if ileus signs occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Fesoterodine with Oliceridine?
MediHelp rates the interaction as moderate. Fesoterodine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastrointestinal transit and can cause urinary retention, and antimuscarinics add to these effects. Together they raise the risk of severe constipation and paralytic ileus.
How serious is the interaction between Fesoterodine and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention and reduced bowel activity, and use a prophylactic bowel regimen. Stop or reduce one agent if ileus signs occur.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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