Drug interactions
Fesoterodine + Orphenadrin
Severity: Moderate
Fesoterodine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so combined use increases anticholinergic adverse effects such as dry mouth, constipation, blurred vision, urinary retention and cognitive impairment. Older patients are at particular risk.
What this interaction means in plain words
Fesoterodine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive antimuscarinic activity.
What to do
Avoid the combination in older patients where possible. Monitor for anticholinergic toxicity, urinary retention and cognitive changes, and reduce or stop one agent if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Orphenadrin?
MediHelp rates the interaction as moderate. Fesoterodine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so combined use increases anticholinergic adverse effects such as dry mouth, constipation, blurred vision, urinary retention and cognitive impairment. Older patients are at particular risk.
How serious is the interaction between Fesoterodine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients where possible. Monitor for anticholinergic toxicity, urinary retention and cognitive changes, and reduce or stop one agent if they occur.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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