Drug interactions
Fesoterodine + Propafenone
Severity: Minor
Fesoterodine and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits CYP2D6 and may increase exposure to the active metabolite of fesoterodine, which could amplify antimuscarinic effects. The effect is expected to be modest because CYP3A4 also contributes to clearance.
What this interaction means in plain words
Fesoterodine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Propafenone belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated metabolism of the active metabolite of fesoterodine.
What to do
Monitor for anticholinergic adverse effects and reduce the fesoterodine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fesoterodine and Propafenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fesoterodine
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Fesoterodine with Propafenone?
MediHelp rates the interaction as minor. Fesoterodine and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propafenone inhibits CYP2D6 and may increase exposure to the active metabolite of fesoterodine, which could amplify antimuscarinic effects. The effect is expected to be modest because CYP3A4 also contributes to clearance.
How serious is the interaction between Fesoterodine and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce the fesoterodine dose if they occur.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
