Drug interactions
Fesoterodine + Quetiapine
Severity: Moderate
Fesoterodine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision, tachycardia and cognitive impairment, particularly in older patients. Reduced gastric motility could also slightly alter oral absorption of quetiapine.
What this interaction means in plain words
Fesoterodine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Quetiapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects of fesoterodine (via 5-hydroxymethyl tolterodine) and quetiapine's anticholinergic metabolite norquetiapine.
What to do
Monitor for anticholinergic adverse effects such as constipation, urinary retention and confusion, especially in elderly patients. Reduce the dose or choose a less anticholinergic agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Fesoterodine with Quetiapine?
MediHelp rates the interaction as moderate. Fesoterodine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision, tachycardia and cognitive impairment, particularly in older patients. Reduced gastric motility could also slightly alter oral absorption of quetiapine.
How serious is the interaction between Fesoterodine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as constipation, urinary retention and confusion, especially in elderly patients. Reduce the dose or choose a less anticholinergic agent if symptoms develop.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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