Drug interactions
Fesoterodine + Rifapentine
Severity: Moderate
Fesoterodine and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and can lower concentrations of the active metabolite of fesoterodine, which may reduce effectiveness. Induction persists for some time after rifapentine is stopped.
What this interaction means in plain words
Fesoterodine and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Rifapentine belongs to Anti Bacterial.
Why it happens
CYP3A4 induction increases metabolic clearance of the active fesoterodine metabolite.
What to do
Monitor for loss of symptom control and consider titrating fesoterodine up to the maximum labeled dose. Reassess after rifapentine therapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fesoterodine with Rifapentine?
MediHelp rates the interaction as moderate. Fesoterodine and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and can lower concentrations of the active metabolite of fesoterodine, which may reduce effectiveness. Induction persists for some time after rifapentine is stopped.
How serious is the interaction between Fesoterodine and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and consider titrating fesoterodine up to the maximum labeled dose. Reassess after rifapentine therapy ends.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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