Drug interactions
Fesoterodine + Secobarbital
Severity: Moderate
Fesoterodine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital is an enzyme inducer and may increase metabolism of fesoterodine's active metabolite via CYP3A4, potentially reducing its effect on bladder symptoms. The effect is likely modest because the metabolite also has CYP2D6 clearance.
What this interaction means in plain words
Fesoterodine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by barbiturates increases clearance of the active metabolite.
What to do
Monitor for reduced symptom control of overactive bladder. Adjust the fesoterodine dose within the labeled range if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Fesoterodine with Secobarbital?
MediHelp rates the interaction as moderate. Fesoterodine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital is an enzyme inducer and may increase metabolism of fesoterodine's active metabolite via CYP3A4, potentially reducing its effect on bladder symptoms. The effect is likely modest because the metabolite also has CYP2D6 clearance.
How serious is the interaction between Fesoterodine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control of overactive bladder. Adjust the fesoterodine dose within the labeled range if response is inadequate.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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