Drug interactions
Fesoterodine + Tiotropium
Severity: Moderate
Fesoterodine and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fesoterodine is an antimuscarinic for overactive bladder and adds to the anticholinergic effects of tiotropium. Dry mouth, constipation, urinary retention and blurred vision may increase.
What this interaction means in plain words
Fesoterodine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Tiotropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for urinary retention, constipation and dry mouth. Reassess the need for both agents if symptoms are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Tiotropium?
MediHelp rates the interaction as moderate. Fesoterodine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fesoterodine is an antimuscarinic for overactive bladder and adds to the anticholinergic effects of tiotropium. Dry mouth, constipation, urinary retention and blurred vision may increase.
How serious is the interaction between Fesoterodine and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and dry mouth. Reassess the need for both agents if symptoms are troublesome.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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