Drug interactions
Fesoterodine + Verapamil
Severity: Minor
Fesoterodine and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and P-glycoprotein inhibitor, and may modestly raise levels of fesoterodine's active metabolite. This could increase antimuscarinic adverse effects, though the effect is generally small.
What this interaction means in plain words
Fesoterodine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by verapamil.
What to do
No empiric dose change is needed. Monitor for dry mouth, constipation and urinary retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Fesoterodine with Verapamil?
MediHelp rates the interaction as minor. Fesoterodine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil is a moderate CYP3A4 inhibitor and P-glycoprotein inhibitor, and may modestly raise levels of fesoterodine's active metabolite. This could increase antimuscarinic adverse effects, though the effect is generally small.
How serious is the interaction between Fesoterodine and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for dry mouth, constipation and urinary retention.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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