Drug interactions
Feverfew + Fondaparinux
Severity: Moderate
Feverfew and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew has in vitro antiplatelet activity and may add to bleeding tendency when combined with fondaparinux. Clinical evidence is limited.
What this interaction means in plain words
Feverfew and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of platelet aggregation by feverfew constituents, adding to factor Xa inhibition.
What to do
Advise patients to avoid feverfew while on fondaparinux, and monitor for bleeding if it is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Feverfew with Fondaparinux?
MediHelp rates the interaction as moderate. Feverfew and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew has in vitro antiplatelet activity and may add to bleeding tendency when combined with fondaparinux. Clinical evidence is limited.
How serious is the interaction between Feverfew and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid feverfew while on fondaparinux, and monitor for bleeding if it is used.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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