Drug interactions
Feverfew + Mefenamic acid
Severity: Moderate
Feverfew and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew has antiplatelet activity in vitro, so combining it with an NSAID that also impairs platelet function and irritates the gastric mucosa may increase bleeding tendency. Clinical evidence is limited and largely theoretical.
What this interaction means in plain words
Feverfew and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet inhibition: feverfew inhibits platelet aggregation and mefenamic acid reversibly inhibits COX-1-mediated thromboxane formation.
What to do
Advise patients to report bruising, melena or other bleeding, and consider stopping feverfew if bleeding signs occur. Avoid the combination in patients with prior GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Feverfew with Mefenamic acid?
MediHelp rates the interaction as moderate. Feverfew and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew has antiplatelet activity in vitro, so combining it with an NSAID that also impairs platelet function and irritates the gastric mucosa may increase bleeding tendency. Clinical evidence is limited and largely theoretical.
How serious is the interaction between Feverfew and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report bruising, melena or other bleeding, and consider stopping feverfew if bleeding signs occur. Avoid the combination in patients with prior GI bleeding.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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